As the mutant signaling transient receptor potential channel 6 (TRPC6) results in an overexpressed nuclear factor of activated T cell (NFATc-1), which cause steroid-resistant nephrotic syndrome and glomerulosclerosis in vivo, the zinc-finger transcription factor Krüppel-like factor 15 (KLF15) binding to the promotor of NFATc-1 increases expression of both nephrin and podocin to ameliorated podocyte injury [237,238]. The gene discussed is NFATC1; the disease is glomerulosclerosis.