We thus hypothesized that combined anti-IL-6/TNF treatment may be beneficial in the context of mixed granulocytic asthma and are reporting here that combined pharmacological inhibition of TNF and IL-6 indeed attenuated granulocyte infiltration in the airways (Figure 1B) and secretion of IgE in the BALF (Figure 1E) in mice exposed to HDM. Here, IL6 is linked to asthma.