TNF and asthma: To this end, we induced acute asthma in BALB/c mice by daily administration (i.n.)of 20 μg HDM per mouse for six days with the sensitization of 5 μg HDM one week prior to the main course, as shown schematically in Figure 1A. Anti-IL-6 antibodies (MP5-20F3) (5 μg/g of body weight) or TNF inhibitor (Etanercept) (10 μg/g of body weight), or the mixture of these two inhibitors and saline as a control were administered intraperitoneally every 48 h for 13 days (Figure 1A).