Using a TNBC cell-SELEX approach, we have recently generated a panel of 6 2′F-Pys RNA aptamers (TN2, TN3, TN20, TN29, TN58, TN145) able to bind at high efficiency to surface proteins of human TNBC cells without recognizing non-malignant cells or non-TNBC breast cancer cells representative of luminal A and HER2-positive subtypes [11]. This evidence concerns the gene ERBB2 and breast cancer.