Nevertheless, until the chronic inflammatory condition occurs in SVD ongoing development, there is an alteration of the M1/M2 passage, with a predominant M1 event; therefore, in SVD patients’ cerebrospinal fluid (CSF), there is a constant growth of oligodendrocyte-derived myelin sheath-like myelin lipid sulfatide (ODMSMS) and myelin essential protein (MBP) due to the massive oligodendrocytes death [102,103,104,105]. The gene discussed is MBP; the disease is snowflake vitreoretinal degeneration.