SERPINE1 and snowflake vitreoretinal degeneration: Other important markers of endothelial altered activation [12,132,133,134] in SVD are intercellular adhesion molecule-1 (ICAM-1), which has been considered as a generic expression of white matter progression [95], soluble thrombomodulin (sTM), interleukin-6 (IL-6), plasminogen activator inhibitor-1 (PAI-1), and von Willebrand factor [129,130,131,132,133,134].