In diabetes, where SVD is a constant presentation form with a crucial endothelial hyper-permeability, a concomitant increase in arteriolar deposition of advanced glycation end products has been observed, which helps and maintains the increase in endothelial permeability through Rho activation and an upregulation of the vascular endothelial growth factor (VEGF) [122,123]. This evidence concerns the gene VEGFA and diabetes mellitus.