ALB and endothelial dysfunction: The superimposition of BBB disruption, endothelial dysfunction, and microvascular fibrosis causes a substantial permeability alteration, with albumin extravasation; the increased CSF/plasma albumin ration is a proven witness of a severe progression of confluency of white matter lesions in SVD [124,125,126,127], together with albuminuria (even if not well-accepted) [128,129,130,131].