EFNB1 and Craniofrontonasal dysplasia: This model was adapted from the concept of metabolic interference proposed by Johnson in 1980 [30], which was used to explain the pattern of inheritance for cranio-frontonasal syndrome (CFNS), a disorder caused by mutations in EFNB1, encoding a protein, ephrin-B1, which is believed to be involved in cellular migration and adhesion [31].