ApoA-I-related amyloidosis represents an intriguing field of study because, despite significant advances in the study of the structure and aggregation propensity of ApoA-I amyloidogenic variants [11,14,15,16,17], (i) the mechanism responsible for the onset and progression of this disease is largely unknown, and (ii) limited therapeutic options are available to counteract the detrimental effect of protein aggregates deposition. Here, APOA1 is linked to amyloidosis.