Notably, Tau was shown to interact with certain central channel FG-Nups, i.e., Nup98 and Nup62, in different ways [12]: The flexible N-terminal part of certain central channel FG-Nups, i.e., Nup98 and Nup62, interacts with soluble Tau in vitro, co-immunoprecipitated with Tau from human AD brain lysates, and accumulates in Tau neurofibrillary tangles in AD brains. This evidence concerns the gene NUP98 and Alzheimer disease.