Subramaniam and Ellis [33] showed that treatment of animals with UMB decreases caspase 3 activation in dopaminergic neurons, demonstrating that the coumarin prevents apoptotic cell death induced by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in a mouse model of Parkinson’s disease. The gene discussed is CASP3; the disease is Parkinson disease.