Furthermore, analyses of time-wise changes in the LG and SG PPAR gamma levels and the activation markers of the NF-κB pathway may pave the way to an enhanced understanding of the pathogenesis of E-FABP involvement in the SS-related dry eye disease since E-FABP ligands may act as peroxisome proliferator-activating receptor γ (PPARγ) ligands during states of increased inflammation [28], and PPARγ is known to induce the expression of the gene associated with cholesterol transportation [29] and to regulate the transcription activation of pro-inflammatory genes in macrophages. The gene discussed is FABP5; the disease is synovial sarcoma.