In a recent in vitro analysis, caspase 1 was also identified as a possible key factor in OLP pathogenesis, since it was associated with the increased expression of the inflammatory TNF-α, IL-1β, IL-6 and IL-18, and positively correlated with the immune-related RAC2, CYBB and ARHGDIB [177]. This evidence concerns the gene IL6 and oral lichen planus.