In a chemical-induced mouse model of colitis, L. fermentum CQPC04 reduced TNF-α, IFN-γ, IL-1β, IL-6, and IL-12, and increased IL-10 release in serum; it also downregulated NF-kB and up-regulated IL-10 expression in colon tissue [114]. The gene discussed is IL1B; the disease is colitis.