L. plantarum YYC-3 cell-free supernatant (CFS) displayed an inhibitory effect on MMP-2 and MMP-9 production when used to treat colorectal cancer HT-29 and Caco-2 cell lines [120], while in human colorectal carcinoma HCT-116 cells, L. casei and LGG CFSs decreased MMP-9 levels, with L. rhamnosus GG displaying also an inhibitory activity on this MMP [121]. This evidence concerns the gene MMP9 and colorectal cancer.