This is the case for HDAC2, KDM5A, KDM4A, KDM3A, KDM5B, KDM1A and EHMT1, that are upregulated, and for SIRT2, HDAC6, HDAC5, KAT2B, SETD2, SETD3 and SMYD1, that are downregulated in HNSCC compared to normal samples [53]. This evidence concerns the gene KDM5B and head and neck squamous cell carcinoma.