DUBs display critical roles in different steps of cancer progression, such as epithelial-to-mesenchymal transition, cell migration, and in the regulation of apoptotic processes, either promoting (USP2, USP7, USP8, USP9X, USP15, USP16, USP17, USP28, USP41, CYLD, UCHL1, A20, and ATXN3) or suppressing apoptosis (USP2, USP9X, USP18, UCHL3, and A20) [72]. This evidence concerns the gene USP2 and cancer.