Several DUBs have been found to play roles in cell cycle control of cancers via the regulation of different cell cycle checkpoints: G1 phase control (e.g., USP3, USP10), G1/S transition (e.g., ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1)), S/G2 transition (e.g., DUB3), and mitotic phase (e.g., USP7). This evidence concerns the gene USP17L2 and cancer.