Inhibition of human ubiquitin specific peptidase 39 (USP39) SUMOylation promotes the USP39-enhanced proliferation of prostate cancer cells [112], and the inhibition of methyl methane sulfonate ultraviolet sensitive gene clone 81 (MUS81) SUMOylation can contribute to tumorigenesis [113]. This evidence concerns the gene USP39 and Familial prostate cancer.