To further confirm the binding specificity of the tribodies for LAG-3, we investigated their binding and biological effects on the HuT78 cell line, which is derived from CD4+ human T cell lymphoma and expresses high levels of LAG-3 receptor, but low or absent levels of PD-1 and PD-L1. This evidence concerns the gene PDCD1 and T-cell non-Hodgkin lymphoma.