CHRNA7 and early-onset autosomal dominant Alzheimer disease: Proteomic profiling in a CHRFAM7A transgenic mouse brain [71] showed that dupα7 overexpression modulates the expression of proteins involved in the α7 nAChR signaling pathways, and that they are related to the pathogenesis of neurological and neuropsychiatric disorders, including Parkinson’s and Alzheimer’s disease.