The great amount of data on CHRFAM7A involvement in neurological and non-neurological disorders reported here, and summarized in Table 2, showed a contrasting effect, being protective in some cases and related to a poor prognosis or a susceptibility gene in the pathogenesis of that disorder in others, but these studies have highlighted the impact of this gene in a variety of α7 nAChR-related disorders. Here, CHRNA7 is linked to nervous system disorder.