α7 nAChR silencing, and treatment with specific agonists, revealed a role for α7 nAChR in controlling joint inflammation in a collagen-induced arthritis rat model of rheumatoid arthritis (RA) [140], and in the synovial tissues and fibroblast-like synoviocytes of patients with RA [62]. The gene discussed is CHRNA7; the disease is rheumatoid arthritis.