Proteomic profiling in a CHRFAM7A transgenic mouse brain [71] showed that dupα7 overexpression modulates the expression of proteins involved in the α7 nAChR signaling pathways, and that they are related to the pathogenesis of neurological and neuropsychiatric disorders, including Parkinson’s and Alzheimer’s disease. This evidence concerns the gene CHRNA7 and Alzheimer disease.