A lack of CHRFAM7A expression in the CD4+ T-lymphocytes of autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) patients [131], a form of epilepsy that is mainly associated with mutations in other nAChR subunits (CHRNA2, CHRNA4 and CHRNB2), suggests that there might be a link between the expression of CHRFAM7A and the occurrence of ADNFLE symptoms [131]. Here, CHRNA4 is linked to autosomal dominant nocturnal frontal lobe epilepsy.