CHRFAM7A and Alzheimer disease: By using median ganglionic eminence (MGE) neuronal progenitors, obtained by the neuronal differentiation of human induced pluripotent stem cells (iPSC) from AD patients with 0 or 1 copies of CHRFAM7A, it has been shown [12,192] that dupα7 decreases the probability of the α7 nAChR channel opening in the presence of the positive allosteric modulator (PAM) PNU 120,596 (PNU) with currents that desensitize faster [192], and this desensitization increases as a function of the CHRFAM7A dosage.