Given the new findings on the functional interdependence between T-type VGCCs, the GABAergic system, APP/GBR complexes, and Aβ formation outlined in this review, it seems likely that pharmacological blockage of LVA T-type VGCCs is a critical factor in the proamyloidogenic scenario associated with increased risk of developing AD, although this needs to be clearly proven in the future. This evidence concerns the gene APP and Alzheimer disease.