In order to test this hypothesis, we analyzed the mRNA expression of proteins involved in the control of adenosine homeostasis in both fibroblasts from patients and brain regions from symptomatic NPC1 mice; in particular, we analyzed the hippocampus and the cerebellum because they are severely affected in NPC, being characterized by atrophy and neuronal degeneration, respectively [5]. Here, NPC1 is linked to nasopharyngeal carcinoma.