As can be seen in Figure 4d, dipyridamole significantly increased the phosphorylation of ERK1/2 both after 5 min (26.25 ± 3.2 in DIP20 5 min vs. 17.4 ± 0.5 in Veh) and 15 min (26.32 ± 1.3 in DIP20 15 min vs. 17.4 ± 0.5 in Veh); the effect of dipyridamole was blocked by the A2AR antagonist SCH58261 (17.2 ± 1.3 in DIP+SCH vs. 26.32 ± 1.3 in DIP20 15 min and 26.25 ± 3.2 in DIP20 5 min). Here, MAPK3 is linked to spindle cell hemangioma.