When the allele and genotype frequencies of 11 tag SNPs across the GLP1R region were assessed in 394 T2DM patients with and 217 patients without coronary artery disease, the rs4714210 GG genotype was associated with lower cardiovascular disease risk and this association remained significant also after adjustment for other known risk factors for cardiovascular disease [67]. The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.