Targeted exome sequencing of six genes encoding drug targets for obesity or T2DM in 11,806 individuals with well-defined metabolic traits, followed by targeted genotyping of 39,979 individuals, reported an association of GLP1R rs10305492 (Ala316Thr) with lower fasting glucose and T2D risk. The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.