Therefore, we next sought detailed structural information of the interaction of MBZ with tubulin using two different macromolecular complexes: T2R-TTL, which is made of two αβ-tubulin heterodimers in complex with one molecule of the stathmin-like domain of RB3 and one molecule of the tubulin tyrosine ligase [6]; and the other, T1D, which includes one αβ-tubulin heterodimer and a synthetic ankyrin repeat protein, DARPin [42]. Here, TTL is linked to type 1 diabetes mellitus.