MAPK3 and colorectal cancer: Here, we present the first finding concerning the discovery of a potent dual inhibitor, 7-methoxy-3-(4-hydroxyl)-styrylchromone (C6): it potently inhibited cytokine production in macrophage-like RAW264.7 cells and induced cell cycle arrest and apoptosis in colorectal cancer HCT116 cells via suppression of HMGB1-RAGE-ERK1/2 signaling pathways.