MAPK3 and cancer: The results of this study show that C6, which was discovered as a papaverine 3D pharmacophore mimetic compound (Table 1), has both potent anti-inflammatory (Figure 2) and anti-cancer (Figure 3 and Figure 4) activities by the suppression of the HMGB1-RAGE-ERK1/2 signaling pathway (Figure 5 and Figure 6), inducing apoptosis to cancer cells (Figure 8).