Furthermore, since the dying cancer cells co-treated with C6 and DNA-damaging agents release HMGB1 from the nucleus to the extracellular milieu and chromosomal HMGB1 is involved in DNA repair mechanisms, such as nucleotide excision repair, base excision repair, and mismatch repair [75,76,77], the DNA repair ability may be extensively reduced by the combination. Here, HMGB1 is linked to cancer.