CASP3 and cancer: On the other hand, in HMGB1-stimulated HCT116 cancer cells, C6 was revealed to suppress the activation of ERK1/2, CDK1, and AKT and the down-regulation of anti-apoptotic XIAP but not c-IAP1, c-IAP2, and Bcl-xL and up-regulate pro-apoptotic Bax and caspase-3/7.