CREB1 and lupus erythematosus: The regulated pathways predicted in TK6 cells were often connected with blood-specific features (e.g., systematic lupus erythematosus in the B-cell signaling pathway and IL-17 signaling) or with apparently irrelevant organs such as the brain (e.g., CREB signaling in neurons and the synaptogenesis signaling pathway) and heart (e.g., cardiac hypertrophy signaling).