The regulated pathways predicted in TK6 cells were often connected with blood-specific features (e.g., systematic lupus erythematosus in the B-cell signaling pathway and IL-17 signaling) or with apparently irrelevant organs such as the brain (e.g., CREB signaling in neurons and the synaptogenesis signaling pathway) and heart (e.g., cardiac hypertrophy signaling). This evidence concerns the gene CREB1 and cardiac hypertrophy.