EIF2A and polycystic ovary syndrome: In fact, endoplasmic reticulum stress (ER) and consequent eIF2α pathway activation directly contribute to the pathogenesis of PCOS by affecting the total health of ovarian follicles and oocytes in several ways, such as induction of interstitial fibrosis, follicular atresia, and accumulation of advanced glycation end products (AGEs) in ovarian granulosa cells [121,122].