Additionally, HSP110 high colorectal tumor biopsies were infiltrated with protumoral macrophages, whereas, those with HSP110 low biopsies were infiltrated with cytotoxic macrophages, indicating that macrophage polarization caused by eHSP110 was probably involved in the poor outcomes of patients with high HSP110 expression [79]. This evidence concerns the gene HSPH1 and colorectal neoplasm.