Various approaches were proposed to explain the mechanism of their anti-tumor activity, which can be attributed to one or more of the following pathways: (1) Tubulin inhibition, (2) Epidermal growth factor receptor (EGFR) inhibition, (3) Inhibition of DNA damage/repair mechanism, and (4) Inhibition of thymidylate synthetase [21,22]. This evidence concerns the gene EGFR and neoplasm.