DNER and cancer: Consequently, the development of inhibitors targeting BET family members has evolved as a promising approach to treat specific cancers [58,59,60,61] Several small molecule BET inhibitors were developed in the recent years with some of them even entering clinical trials for cancer therapies such as I-BET762/GSK-525762A, TEN-010, JQ1, ODM-207, ABBV-075, and a quinazolone based BET inhibitor—Apabetalone (RVX-208) developed by Resverlogix (Figure 11) [62,63].