EGFR and cancer: In addition to the inhibition of EGFR phosphorylation, compound 15 successfully demonstrated induction of hyperacetylation of histone H3 on the cellular level, and it showed excellent anti-proliferative activities against five cancer cell lines (A549, BT-474, A431, SK-BR-3, and NCI-H1975) with IC50 in the range of 0.2–7.8 μM (Table 20) [83].