PCNA and bacterial infectious disease: However, the antibiotics could improve diabetic wound healing via controlling the bacterial infection, increasing the innate immune cells infiltration, but unfortunately, they negatively impacted the fibroblast and keratinocytes’ viability, proliferative capacity, and, consequently, the matrix proteins’ formation and re-epithelialization that was shown with the reduced expression of the PCNA and the upstream expression of the apoptotic pathway.