APC and alopecia: In addition, clarifying the contribution rate of each of the subunits Gs, Gi/o, and Gq/11 and further study with adenosine receptor knock-out and Gα subunit inhibitors (cholera toxin, pertussis toxin, and UBO-QIC) will be helpful to understand the more precise mechanism of adenosine and to elucidate the effective therapeutic targets of alopecia treatment [53,54].