Even though the processes connecting BrCa and obesity are complicated, increased influence of adipokines and inflammatory cytokines, as well as increases in circulating insulin and insulin-like growth factors, local estrogen synthesis in adipose tissue, and the impact of circulating insulin and insulin-like growth factors, are all thought to play a role in disease development [25]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.