Andrographolide (Andro), a major component of the medicinal plant Andrographis paniculata, promotes the differentiation of imatinib-sensitive and imatinib-resistant CML cells through the production of ROS, which prompts BCR-ABL downregulation and Hsp90 cleavage. Here, BCR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.