SOX2 and pancreatic ductal adenocarcinoma: So far, several SOX genes (SOX4, SOX9, SOX10, SOX11, and SOX12) have been shown to be enriched in the developing human pancreas, while some also remain actively expressed in adult pancreatic islets (SOX4 and SOX9) and are reactivated during the initiation of pancreatic ductal adenocarcinoma (SOX4, SOX9 and SOX18) or involved in therapy resistance (SOX2) [15,16,17,18,19].