MAPK8 and cancer: In HCT 116, K562, KB, and T47D cancer cell lines, DET (7.46, 4.02, 3.35, and 1.86 μg/mL, respectively) attenuated the phosphorylation levels of ERK1/2, and increased the phosphorylation levels of SAPK/JNK and p38 MAPK without changing the protein expression level of ERK1/2, SAPK/JNK, or p38 MAPK [64].