IDET (10 μM) inhibited the constitutive activation of NF-κB in human myeloma MM.1S and U266 cells, as well as head and neck squamous cell carcinoma SCC4 and LICR-LON-HN5 cells, which are known to express constitutive NF-κB activation. The gene discussed is NFKB1; the disease is plasma cell myeloma.