DET (4.14 μg/mL; 48 h) downregulated Bcl-2 and Bcl-XL and upregulated Bax at mRNA, thus altered the Bax/Bcl-2 ratio at the mRNA level with the activation of caspase-9, -7, and -3, released cytochrome c in cytosol, and induced PARP cleavage in cervical carcinoma SiHa cells [30]. The gene discussed is BAX; the disease is cervical carcinoma.