Several studies have shown that DETD-35 induces ROS-mediated apoptosis through multiple pathways, including Bcl-2 family protein modulation, dissipation of ΔΨm, cell cycle arrest at the G2/M phase, the inhibition of ERK phosphorylation, the induction of autophagy, and the inhibition of metastasis in various cancer cells, including melanoma and triple negative breast cancer cells [81,115,116,117]. Here, BCL2 is linked to cancer.