EP300 and acute myeloid leukemia: Even more importantly, the overexpression of MYB in AML cells (in case of HAC und HM also overexpression of C/EBPβ) was found to significantly decrease the sensitivity of the cells towards all of the natural products under study, which clearly shows that inhibition of the MYB-p300-C/EBPβ module does indeed contribute an important part to these compounds’ antitumoral mechanism of action.