In previous studies, we have found that the pharmacological blockade of the CB1 or CB2 receptor signalling pathways impairs (by targeting the mitochondrial unfold protein response (UPRmt)) the in vitro proliferation of human GBM cells obtained from the core region (U87) suggesting that CB2 cannabinoid receptors are somehow involved in the proliferation of these GBM cells [18]. Here, CNR1 is linked to glioblastoma.