PIK3CA and encephalocraniocutaneous lipomatosis: In congenital infiltrating lipomatosis of the face (CILF), diffuse lipomatosis (DL), encephalocraniocutaneous lipomatosis (ECCL), PTEN hamartoma of soft tissue (PHOST) and PIK3CA-related overgrowth spectrum (PROS), continued growth and/or recurrence after incomplete resection is common and can lead to disrupted growth, malformation and malfunction, sometimes requiring multiple surgeries in [10,58,60].