Therefore, polymorphisms of many immune-related genes are associated with susceptibility to aspergillosis, such as tumor necrosis factor receptor 1 (TNFR1), TLR1/4/5/6, Dectin-1, DC-SIGN, IL-8, IL-10, IL-12, IL-4R, IFN-γ, IRF4 and so on [8,9,10,29,30,31,32,33,34,35]. Here, IRF4 is linked to aspergillosis.