The CC homozygote of rs34531240 and rs28438857, GG homozygote of rs3995818, TT homozygote of rs3995817 in NLRC5 were all more frequent in IPA patients than controls (p = 0.0420; OR = 2.386, 95%CI: 0.9749 to 5.567). The gene discussed is NLRC5; the disease is Ito hypomelanosis.