The CC homozygote (p = 0.0004; OR = 4.861, 95%CI: 2.007 to 11.9) and C allele (p = 0.0117; OR = 2.115, 95%CI: 1.196 to 3.741) of NLRP3 rs3806265, as well as TT homozygote of NLRC5 rs1684579 (p = 0.0036; OR = 3.385, 95%CI: 1.47 to 8.101) were associated with a higher risk of IPA and the genotype differences of them were significant between IPA patients and controls (p = 0.0017; p = 0092). This evidence concerns the gene NLRP3 and Ito hypomelanosis.