For the first time, we found rs3806265 in NLRP3, rs212704 in NLRC4 and rs12598522, rs34531240, rs28438857, rs3995818, rs3995817, rs1684579 in NLRC5 were associated with pulmonary aspergillosis in non-neutropenic patients. The gene discussed is NLRC5; the disease is aspergillosis.