In the construction of ROC curves of complications and annual survival after ischemic stroke or applied revascularization, a multimodal approach is used that combines a number of biomarkers, i.e., variables using NIHSS, cIMT, age, IL-6, TNF-α, hsCRP, HDL, protein C, protein S, vWF, and platelet endothelial cell adhesion molecule 1 (PECAM-1), which have a larger area under the curve (AUC/ROC), i.e., 0.975 (accuracy ca. 93%, 100% sensitivity, and 85.7% specificity) than either indicators separately [127]. The gene discussed is PECAM1; the disease is ischemic stroke.