We found that SLE patients with CRP levels ≥ 3 mg/L had a significantly higher risk of presenting clinical disease activity with a Mex-SLEDAI ≥ 2 (OR = 2.5; CI = 1.03–6.2; p = 0.04), higher risk of having a high LAP score ≥ Tertile 3rd (OR = 3.01; CI = 1.04–8.7; p = 0.04), higher risk of a triglycerides/HDL-C index score ≥ 3 (OR = 5.2; IC = 2.1–12.8; p < 0.001), Kannel index score ≥ 3 (OR = 3.1; IC = 1.1–8.1; p = 0.03), and Castelli index score ≥ 7 (OR = 6.6; IC = 2.5–17.8; p < 0.001) in comparison with SLE patients with CRP < 1 mg/L (Figure 2). This evidence concerns the gene CRP and systemic lupus erythematosus.