A study conducted on SLE patients from Brazil showed an association between rs1130864 CRP polymorphism and SLE susceptibility [39], while Enocsson et al. reported that IFN-α downregulates CRP expression, and the rs1205 CRP polymorphism could explain the low basal CRP and the inadequate CRP responses among active SLE patients [40]. The gene discussed is CRP; the disease is systemic lupus erythematosus.