ADAMTS13 and thrombotic thrombocytopenic purpura: Nevertheless, the present and previous evidence suggest that as LC progresses, ADAMTS13:AC and VWF:Ag levels change more gradually than Et levels and that IgG type of ADAMTS13:INH that meets the diagnostic criteria for TTP was detected in some patients with end-stage cirrhosis; especially a marked decrease in ADAMTS13:AC (i.e., <3%) [20].