Because the hemodynamic effects of portal hypertension (PHT) can induce hepatic encephalopathy [41], HRS [42], and ascites [43], it is possible that ADAMTS13:AC and VWF:Ag are associated with these conditions through Et-induced development of hepatic encephalopathy, HRS, ascites, and subsequent PHT. This evidence concerns the gene VWF and pulmonary hypertension, primary, 1.