HSCs are the major ADAMTS13-producing cells in the liver [18]; thus, previous studies have focused on the potential role of ADAMTS13 in the pathophysiology of liver diseases associated with sinusoidal and/or systemic microcirculatory disturbances [8,12,14,15,20,21,22,24,25,26,27]. The gene discussed is ADAMTS13; the disease is liver disorder.