PLOD1 and hypogonadotropic hypogonadism: Boys/girls with a disorder of pubertal development, as previously described, reduced growth rate, low values of LH, FSH, 17β-estradiol in females, and of total testosterone in males, with a lack of pubertal development after 1–2 cycles of pubertal induction with low-dose hormones, have hypogonadotropic hypogonadism.