Markers of acute inflammatory response including CRP (OR (95% CI): 1.014 (1.008–1.020), p < 0.001 per 1 mg/L increase) and ferritin (OR (95% CI): 1.001 (1.000–1.001, p = 0.030 per 1 ng/mL increase), hypercoagulability (fibrinogen OR (95% CI): 1.009 (1.005–1.014), p < 0.001 per 1 mg/dL increase), cell death (LDH OR (95% CI): 1.007 (1.004–1.010), p < 0.001 per 1 U/L increase) or liver dysfunction (γ-GT OR (95% CI): 1.010 (1.004–1.016), p = 0.001 per 1 U/L increase) were all associated with increased risk of developing critical disease (Table 2). The gene discussed is CRP; the disease is thrombophilia.