SERPINE1 and thrombophilia: The formation of ROS results in the production of inflammatory factors, such as tumour necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), tissue factor (TF), nuclear factor kappa B (NF-κB), IL-6, CRP, and plasminogen activator inhibitor-1 (PAI-1), which may add to the state of overwhelming systemic inflammation, and hypercoagulability [12].