The significant increases in the number of reticulocyte were observed in both β0-thalassemia/HbE and IDA compared to normal control (Table 1), but when comparing in the same Hb levels group, the β0-thalassemia/HbE patients had significantly higher reticulocyte counts and proportions of immature fraction than IDA patients did (p ≤ 10−5). The gene discussed is GSTM1; the disease is thalassemia.