APP and Alzheimer disease: Hsp-inspired, mixed-shell polymeric micelle (MSPM) based self-assembling nanochaperone is one of the chaperone-aiding ENPs which selectively captures Aβ peptides, suppress the Aβ aggregate formation process and reduce cytotoxicity mediated by Aβ, facilitate Aβ clearance thereby, reducing Aβ burden, attenuate Aβ-induced inflammation and were able to rescue cognitive deficits in APP/PS1 transgenic AD mice indicating the potential application of MSPM based nanochaperones for prophylactic treatment of AD and prevention of the onset of AD-like symptoms [105].