SIRT1 and Obesity: Besides, a high dose of GA also elevated the level of allyl isothiocyanate, a potential therapeutic agent for obesity and insulin resistance, not only improves lipid accumulation and inflammation in a fatty liver via Sirt1/AMPK and NF-κB signaling pathways, but also induces Nrf2 activation and increases HO-1 expression as a liver protective agent [60].