Of note is the fact that different groups have found that inoculation of SOD1 aggregates prepared from spinal cord not only from transgenic mice overexpressing mutant SOD1s but also from SOD-ALS patients carrying mutant SOD1s expressed at endogenous levels are able to transmit both SOD1 aggregation and fatal motor neuron disease to transgenic mice [30,31]. This evidence concerns the gene SOD1 and motor neuron disorder.