By using cPLA2 knockout mice, the group of Bonventre and Force has shown that cPLA2 mitigates both normal and TAC-induced cardiac pathological hypertrophy, limiting growth factor IGF1 signaling, via AA-induced translocation to the membrane and activation of PKCζ and PDK1, pivotal players in cardiac hypertrophy [126,127]. The gene discussed is PLA2G4A; the disease is cardiac hypertrophy.