Unrelated to this previously identified TNFR2-ORAI3 pathway, our recent study shows that synergistic action of TNFα with the chemokine CX3CL1 promoted adaptive cardiac concentric hypertrophy in response to early β-AR chronic stimulation and limited transition toward eccentric dilated remodeling (low h/r geometric parameter) and HF [5]. This evidence concerns the gene ORAI3 and cardiac hypertrophy.