S100B and myocardial infarction: Experimentally, serum concentrations of S100 proteins such as S100B, S100A6 and S100P (a small, 10.4 kDa calcium-binding protein) are associated with the severity of MI in rat ischemia–reperfusion models and in clinic studies are increased in patients with ACS, particularly in those with ST-segment elevation MI (STEMI) [69].