The mitogen-activated protein kinase (MAPK) signal transduction cascade is physiologically stimulated upon the binding of growth factors to a receptor tyrosine kinase (RTK) on the cellular surface and the recruiting of a large network of serine-or tyrosine kinases via subsequent activation of the rat sarcoma (RAS), rapidly accelerated fibrosarcoma (RAF), mitogen-activated protein kinase (MEK), extracellular signal-regulated kinase (ERK) pathway to execute cellular functions such as cell-cycle progression, de-differentiation, and anti-apoptotic events [7,8]. Here, WNK2 is linked to sarcoma.