POLR2A and cancer: Moreover, although we did not carry out experimental confirmation, nearly all of the necroptosis and propanoate metabolism genes and their interacting partners in Figure 6c,d (MRPS16, VHL, LIMD1, NDUFC2, PCCB, ACOX1, LONP2, XIAP, RPL37A, EIF2AK2, PGAM5, MAVS, TIAL1, XPOT, NUP43, TEP1, SNRPD3, EIF3M, and MAGT1) or their paralogs (COX18/COX20, GTF2H3/GTF2H2, SLC25A3/SLC25A21, PLBD2/PLBD1, RPL14/RPL13, IFNAR1/IFNAR2, and POLR2D/POLR2A) have been shown to be editing targets in HepG2 cells [69], lung cancer [29], or during epithelial-mesenchymal transition in several cancer types [27].