Based on prior reports on ATXN3 mRNA and that of other CAG repeat disorders [25,26,27,28,29], SCA3/MJD toxicity may be influenced by the ability of ATXN3 mRNA to form secondary structures and by the presence of polyA species that have been observed in SCA3/MJD tissue [30]. This evidence concerns the gene ATXN3 and Spinocerebellar ataxia type 3.