ATXN3 and Spinocerebellar ataxia type 3: We took advantage of the genetic versatility of Drosophila melanogaster models of SCA3/MJD to express versions of human ataxin-3 transgenes with the native homomeric CAG or interrupted alternating CAGCAA repeats that are, respectively, more and less likely to form the secondary structure necessary to enable RAN translation.