As a multifunctional oncoprotein, YB-1 has been shown to be overexpressed and is often associated with poor prognoses in human cancers, such as breast cancer [21], ovarian cancer [22], liver cancer [23], lung cancer [24], colorectal cancer [25], prostate cancer [26], multiple myeloma [27], melanoma [28], osteosarcoma [29], glioblastoma [30], mesothelioma [31], and urothelial carcinoma of the bladder [32]. The gene discussed is YBX1; the disease is osteosarcoma.