Linc00665 directly interacts with the YB-1 protein to promote its stabilization, leading to the nuclear accumulation of YB-1, acting as a transcription factor to activate the expression of angiopoietin-like protein 3/4 (ANGPTL3/4) to promote angiogenesis in lung adenocarcinoma [119]. This evidence concerns the gene YBX1 and lung adenocarcinoma.