HMGB1 and cancer: PDT based on pz I and pz III effectively kills fibrosarcoma MCA205 cells through the immunogenic pathway accompanied by the emission from PDT-induced cancer cells of two crucial DAMPs (ATP and HMGB1) with subsequent engulfment by antigen-presenting cells (i.e., dendritic cells, DC) and induction of their activation and maturation in vitro [47].